PUBLICATIONS



2024

Li S, Li W, Miao Y, Gao M, Jia Y, Chen Z, Chen X, Pan T, Zhang S, Xing Z, Han S, Sun XL, Wei X, Liu Z, Zhou W, Wu W, Liu F, Han L, Zhu H, Ye H, Liu L, Li Y, Zhang P, Gong J, Tian Y, Ai Y, Cao P, Wu D, Qi X, Gui S, Wu QF*. Modeling craniopharyngioma for drug screening reveals a neuronal mechanism for tumor growth. Sci Transl Med. 2024 Dec 18;16(778):eadn6763.

Yu S#, Huang F#, Huang Y#, Yan F, Li Y, Xu S, Zhao Y, Zhang X, Chen R*, Chen X*, Zhang P*. Deciphering the influence of gut and oral microbiomes on menopause for healthy aging. J Genet Genomics. 2024 Nov 20;. doi: 10.1016/j.jgg.2024.11.010.

Liang J#, Huang F#, Hao X#, Zhang P*, Chen R*. Nicotinamide mononucleotide supplementation rescues mitochondrial and energy metabolism functions and ameliorates inflammatory states in the ovaries of aging mice. MedComm. 2024 Oct;5(10):e727.

Huang F#, Chen J#, Zhou M#, Tang R, Xu S, Zhao Y, Su M, Zhang X, Zhang P*, Chen R*. Dysbiosis of the oral-gut microbiome in PCOS patients and its implication for noninvasive diagnosis. Clin Transl Med. 2024 Aug;14(8):e70001. doi: 10.1002/ctm2.70001.

Leng F, Mei S, Zhou X, Liu X, Yuan Y, Xu W, Hao C, Guo R, Hao C*, Li W*, Zhang P*. DVsc: An Automated Framework for Efficiently Detecting Viral Infection from Single-cell Transcriptomics Data. Genomics Proteomics Bioinformatics.. 2024 Jul 3;22(2).

Wan Z, Jiang N, Su M, Zhang X, Cao Y, Wu A, Zhang P*, Jiang T*. Multiscale fusion network drives the repurposing of anticancer drugs. Clin Transl Med. 2024 Jul;14(7):e1745.

Huang F, Cao Y, Liang J, Tang R, Wu S, Zhang P*, Chen R*. The influence of the gut microbiome on ovarian aging. Gut Microbes. 2024 Jan;16(1):2295394.


2023

Wu Z#, Zhang X#, An Y, Ma K, Xue R, Ye G, Du J, Chen Z, Zhu Z, Shi G, Ding X, Wan M, Jiang B, Zhang P*, Liu J*, Bu P*. CLMP is a tumor suppressor that determines all-trans retinoic acid response in colorectal cancer. Developmental Cell. 2023 Nov 2:S1534-5807(23)00525-7.

Bailey C#, Wei Y, Yan J, Huang D, Zhang P, Qi C, Lazarski C, Su J, Tang F, Wong CS, Zheng P, Liu Y*, Liu Y*, Wang Y*. Genetic and pharmaceutical targeting of HIF1α allows combo-immunotherapy to boost graft vs. leukemia without exacerbation graft vs. host disease. Cell Reports Medicine. 2023 Oct 3:101236.

Yu S#, Chen J#, Yan F, Chen X*, Zhao Y*, Zhang P*. Intratumoral Leptotrichia is a novel microbial marker for favorable clinical outcomes in head and neck cancer patients. MedComm. 2023 Aug 27;4(5):e344.

Yu S#, Chen J#, Zhao Y#, Yan F, Fan Y, Xia X, Shan G, Zhang P*, Chen X*. Oral-microbiome-derived signatures enable non-invasive diagnosis of laryngeal cancers. Journal of Translational Medicine. 2023 ul 5;21(1):438.

Mei S#, Huang Y#, Zhao Y, Zhang X, Zhang P*. A pan-cancer blueprint of genomics alterations and transcriptional regulation of Siglecs, and implications in prognosis and immunotherapy responsiveness. Clinical and Translational Medicine. 2023 May;13(5):e1262

Zhang Z, Li H, Weng H, Zhou G, Chen H, Yang G, Zhang P, Zhang X, Ji Y, Ying K, Liu B, Xu Q, Tang Y, Zhu G, Liu Z, Xia S, Yang X, Dong L, Zhu L, Zeng M, Yuan Y, Yang Y, Zhang N, Xu X, Pang W, Zhang M, Zhang Y, Zhen K, Wang D, Lei J, Wu S, Shu S, Zhang Y, Zhang S, Gao Q, Huang Q, Deng C, Fu X, Chen G, Duan W, Wan J, Xie W, Zhang P, Wang S, Yang P, Zuo X*, Zhai Z*, Wang C*. Genome-wide association analyses identified novel susceptibility loci for pulmonary embolism among Han Chinese population. BMC Medicine. 2023 Apr 19;21(1):153.

Zhang P*, Zhao Y, Xia X, Mei S, Huang Y, Zhu Y, Yu S, Chen X*. Expression of OLR1 gene on tumor-associated macrophages of head and neck squamous cell carcinoma, and its correlation with clinical outcome. Oncoimmunology. 2023 Apr 18;12(1):2203073.

Liu M, Wang X, Du X, Wu W, Zhang Y, Zhang P, Ai C, Devenport M, Su J, Muthana MM, Su L, Liu Y, Zheng P. Soluble CTLA-4 mutants ameliorate immune-related adverse events but preserve efficacy of CTLA-4- and PD-1-targeted immunotherapy. Science Translational Medicine. 2023 Mar;15(685):eabm5663.


2022

Zeng Q, Saghafinia S, Chryplewicz A, Fournier N, Christe L, Xie YQ, Guillot J, Yucel S, Li P, Galván JA, Karamitopoulou E, Zlobec I, Ataca D, Gallean F, Zhang P, Rodriguez-Calero JA, Rubin M, Tichet M, Homicsko K, Hanahan D. Aberrant hyperexpression of the RNA binding protein FMRP in tumors mediates immune evasion. Science. 2022 Nov 18;378(6621):eabl7207.

Zhao Y#, Mei S#, Huang Y, Chen J, Zhang X, Zhang P*. Integrative analysis deciphers the heterogeneity of cancer-associated fibroblast and implications on clinical outcomes in ovarian cancers. Comput Struct Biotechnol J. 2022;20:6403-6411. doi: 10.1016/j.csbj.2022.11.025.

Xu Z, Murad N, Malawsky D, Tao R, Rivero-Hinojosa S, Holdhof D, Schuller U, Zhang P, Lazarski C, Rood B, Packer R, Gershon T and Yanxin Pei. OLIG2 is a determinant for the relapse of MYC-amplified medulloblastoma. Clinical Cancer Research. 2022 May 26;clincanres.0527.2022-3-18.

Yuan X, Zhang P*. Revisiting benchmark study for response to methodological critiques of 'Evaluation of phenotype-driven gene prioritization methods for Mendelian diseases'. Briefings in Bioinformatics. 2022 May 5;bbac181.

Wang X, Liu M, Zhang J, Brown NK, Zhang P, Zhang Y, Liu H, Du X, Wu W, Devenport M, Tao W, Mao-Draayer Y, Chen GY, Chen YE, Zheng P, Liu Y. CD24-Siglec axis is an innate immune checkpoint against metaflammation and metabolic disorder.  Cell Metabolism. 2022 Aug 2;34(8):1088-1103.e6.

Yuan X, Wang J, Dai B, Sun Y, Zhang K, Chen F, Peng Q, Huang Y, Zhang X, Chen J, Xu X, Chuan J, Mu W, Li H, Fang P, Gong Q*, Zhang P*. Evaluation of phenotype-driven gene prioritization methods for Mendelian diseases. Briefings in Bioinformatics. 2022 Mar 10;23(2)

Zhao Y#, Chen J#, Hao Y, Wang B, Wang Y, Liu Q, Zhao J, Li Y, Wang P, Wang X*, Zhang P*, Zhang L*. Predicting the recurrence of chronic rhinosinusitis with nasal polyps using nasal microbiota. Allergy. 2022 Feb;77(2):540-549.


2021

Zhang X#, Lian P#, Su M#, Ji Z, Deng J, Zheng G, Wang W, Ren X, Jiang T, Zhang P*, Li H*. Single-cell transcriptome analysis identifies a unique tumor cell type producing multiple hormones in ectopic ACTH and CRH secreting pheochromocytoma. Elife. 2021 Dec 14;10:e68436.

Huang Y, Zhang P*. Immunogenomic alterations of head and neck squamous cell carcinomas stratified by smoking status. Clinical and Translational Medicine. 2021 Nov;11(11):1-5.

Huang Y, Zhang P*. Evaluation of machine learning approaches for cell-type identification from single-cell transcriptomics data. Briefings in Bioinformatics. 2021 Sep 2;22(5).

Liu Y*, Nelson MV, Bailey C, Zhang P, Zheng P, Dome JS, Liu Y*, Wang Y*. Targeting the HIF-1α-IGFBP2 axis therapeutically reduces IGF1-AKT signaling and blocks the growth and metastasis of relapsed anaplastic Wilms tumor. Oncogene. 2021 Jul;40(29):4809-4819.

Huang Y, Zhang P*. Transcriptomic profiling of tumor microenvironment reveals distinct immune subgroups of metastatic melanoma and its potential implications for immunotherapy. Journal of Genetics and Genomics. 2021 May 20;48(5):426-428.

Zhang P, Liu M, Cui Y, Liu Y*, Zheng P*. Microsatellite Instability Status Differentially Associates with Intratumoral Immune Microenvironment in Human Cancers. Briefings in Bioinformatics. 2021 May 20;22(3).

Zhang P*, Huang Y. Genomic alterations in KMT2 family predict outcome of immune checkpoint therapy in multiple cancers. Journal of Hematology & Oncology. 2021 Mar 2;14(1):39.

Wu X, Nelson M, Basu M, Srinibasan P, Lazarski C, Zhang P, Zheng P, Sandler A*. The MYC oncogene is associated with suppression of tumor immunity and targeting Myc induces tumor cell immunogenicity for therapeutic whole cell vaccination. Journal for Immunotherapy of Cancer. 2021 Mar;9(3).

Ye X, Pei F, Liu J, Zhao H, Chen W, Wang H, Zhang P*, Huang X*. IPPC: An Interactive Platform for Prostate Cancer Multi-Omics Data Integration and Analysis. Journal of Molecular Cell Biology. 2021 Jan 25;mjab004.


2020

Xin C, Zhu J, Gu S, Yin M, Ma J, Pan C, Tang J, Zhang P, Liu Y, Bai XF, Mo X, Xu M, Zhu H. CD200 Is Overexpressed in Neuroblastoma and Regulates Tumor Immune Microenvironment. Cancer Immunology, Immunotherapy. 2020 Nov;69(11):2333-2343.

Fu Y, Huang X, Zhang P, Leemput J, Han Z. Single-cell RNA sequencing identifies novel cell types in Drosophila blood. Journal of Genetics and Genomics. 2020 Apr 20;47(4):175-186.

Wang Y, Liu Y, Bailey C, Zhang H, He M, Sun D, Zhang P, Parkin B, Baer MR, Zheng P, Malek SN, Liu Y. Therapeutic targeting of TP53-mutated acute myeloid leukemia by inhibiting HIF-1α with echinomycin. Oncogene. 2020 Apr;39(14):3015-3027.


2019

Zhang P#, Peter C#, Young L, Zheng P*, Liu Y*. En Masse Discovery of Anti-Cancer Human Monoclonal Antibodies by De novo Assembly of immunoglobulin Sequences from Transcriptomes and Genome Sequences of Cancer Tissues. Cellular & Molecular Immunology. 2019 Dec;16(12):943-945.

Zeng Q, Michael IP, Zhang P, Saghafinia S, Knott G, Jiao W, McCabe BD, Galván JA, Robinson HPC, Zlobec I, Ciriello G, Hanahan D. Synaptic proximity enables NMDAR signaling to promote brain metastasis. Nature. 2019 Sep;573(7775):526-531.

Zhang Y#, Du X#, Liu M#, Tang F, Zhang P, Ai C, Fields J, Sundberg E, Latinovic O, Devenport M, Zheng P*, Liu Y*. Hijacking Antibody-induced CTLA-4 Lysosomal Degradation for Safer and More Effective Cancer Immunotherapy. Cell Research. 2019 Aug;29(8):609-627.

Tao R, Murad N, Xu Z, Zhang P, Okonechnikov K, Kool M, Rivero-Hinojosa S, Lazarski C, Zheng P, Liu Y, Eberhart CG, Rood BR, Packer R, Pei Y. MYC drives Group 3 medulloblastoma through transformation of Sox2+ astrocyte progenitor cells. Cancer Research. 2019 Apr 15;79(8):1967-1980.

Flores R, Zhang P, Wu W, Wang X, Ye P, Zheng P*, Liu Y*. Siglec Genes Confer Resistance to Systemic Lupus Erythematosus in Human and Mouse. Cellular & Molecular Immunology. 2019 Feb;16(2):154-164.


2018

Tian RR, Zhang MX, Zhang LT, Zhang P, Ma JP, Liu M, Devenport M, Zheng P, Zhang XL, Lian XD, Ye M, Zheng HY, Pang W, Zhang GH, Zhang LG*, Liu Y*, Zheng YT*. CD24 and Fc fusion protein protects SIVmac239-infected Chinese rhesus macaque against progression to AIDS. Antiviral Research. 2018 Sep;157:9-17.

Du X#, Tang F#, Liu M, Su J, Zhang Y, Wu W, Devenport M, Lazarski C, Zhang P, Wang X, Ye P, Wang C, Hwang E, Zhu T, Xu T, Zheng P*, Liu Y*. A reappraisal of CTLA-4 checkpoint blockade in cancer immunotherapy. Cell Research. 2018 Apr;28(4):416-432.

Du X#, Liu M#, Su J, Zhang P, Tang F, Ye P, Devenport M, Wang X, Zhang Y, Liu Y*, Zheng P*. Uncoupling Therapeutic from Immunotherapy-related Adverse Effects for Safer and Effective Anti-CTLA-4 Antibodies in CTLA4 Humanized Mice. Cell Research. 2018 Apr;28(4):433-447.


2017

Tang F, Zhang P, Ye P, Lazarski CA, Wu Q, Bergin IL, Bender TP, Hall MN, Cui Y, Zhang L, Jiang T, Liu Y*, Zheng P*. A Population of Innate Myelolymphoblastoid Effector Cell Expanded by Inactivation of mTOR Complex 1. Elife. 2017 Dec 5;6. pii: e32497.

Zhang P, Wu X, Basu M, Dong C, Zheng P*, Liu Y*, Sandler AD*. MYCN amplification is associated with repressed cellular immunity in neuroblastoma: an in silico immunological analysis of TARGET database. Frontiers in Immunology. 2017 Nov 3;8:1473.

Lee YH#, Martin-Orozco N#, Zheng P, Li J, Zhang P, Tan H, Park HJ, Jeong M, Chang SH, Kim BS, Xiong W, Zang W, Guo L, Liu Y, Dong ZJ, Overwijk WW, Hwu P, Yi Q, Kwak L, Yang Z, Mak TW, Li W, Radvanyi LG, Ni L, Liu D, Dong C. Inhibition of B7-H3 checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function. Cell Research. 2017 Aug;27(8):1034-1045.

Li CS#, Tang F#, Zhang P, Jiang T, Saunders TL, Zheng P*, Liu Y*. Trap1a is an X-linked and cell-intrinsic regulator of thymocyte development. Cellular & Molecular Immunology. 2017 Aug;14(8):685-692.


2016

Cui Y, Chen X, Luo H, Fan Z, Luo J, He S, Yue H, Zhang P, Chen R. BioCircos.js: an interactive Circos JavaScript library for biological data visualization on web applications. Bioinformatics. 2016 Jun 1;32(11):1740-2.

Qin S#, Yin H#, Yang C, Dou Y, Liu Z, Zhang P, Yu H, Huang Y, Feng J, Hao J, Hao J, Deng L, Yan X, Dong X, Zhao Z, Jiang T, Wang HW, Luo SJ, Xie C. A magnetic protein biocompass. Nature Materials. 2016 Feb;15(2):217-26.


2015

Yu H#, Zhang P#, Yin X, Yin Z, Shi Q, Cui Y, Liu G, Wang S, Piccaluga PP, Jiang T*, Zhang L*. Human BDCA2+CD123+CD56+ dendritic cells (DCs) related to blastic plasmacytoid dendritic cell neoplasm represent a unique myeloid DC subset. Protein & Cell. 2015 Apr;6(4):297-306.


2014

Zeng Q#, Zhang P#, Wu Z#, Xue P, Lu D, Ye Z, Zhang X, Huang Z, Feng J, Song L, Yang D, Jiang T*, Yan X*. Quantitative proteomics reveals ER-α involvement in CD146-induced epithelial-mesenchymal transition in breast cancer cells. Journal of Proteomics. 2014 May 30;103:153-69.

Laboratory of Zhang
Division of Immunotherapy
University of Maryland
zhangpengdyx@aliyun.com
725 West Lombard Street,
Baltimore, MD 21201